The effects of lesions to the striatum on the function of the hypothalamo-hypophyseal-adrenal system in adrenalectomized rats.

Experiments on white rats were performed to study the effects of bilateral lesioning of the striatum on activation of the hypothalamo-hypophyseal-adrenal system (HHAS) after unilateral adrenalectomy. These studies showed that increases in the weight of the surviving adrenal gland were smaller in striatectomized rats than in controls. There was a significant decrease in corticosteroid production by the intact gland. These changes were most marked after destruction of the dorsal parts of the nucleus. These data provide evidence for involvement of the striatum in controlling HHAS activity via a feedback mechanism.

[Effect of striatum destruction on the hypothalamo-pituitary-adrenal axis function in adrenalectomized rats]. / Vliianie povrezhdeniia striatuma ha funktsiiu gipotalamo-gipofizarno-nadpochechnikovoi sistemy u adrenaléktomirovannykh krys.

The influence of the bilateral striatectomy on activation of the hypothalamus-pituitary-adrenal axis after unilateral adrenalectomy was investigated. Increasing of the intact adrenal gland's mass in striatectomized rats was less than in the control group. It was combined with decreasing of the production of corticosteroids by intact gland. Such disturbances were more obvious in rats with destruction of the dorsal striatum than the ventral one. These facts suggest the striatum participation, its dorsal zone in particular, in the processes of regulation of the hypothalamus-pituitary-adrenal axis.

[The role of echography in the complex dynamic examination of patients with retardation of sexual development]. / Rol' ékhografii v kompleksnom dinamicheskom nabliudenii za bol'nymi s zaderzhkoi polovogo sozrevaniia.

Seventy-nine patients with sexual development retardation were examined, 24 of these suffered from ovarian genesis condition and 55 from central genesis condition. The findings evidence that detection of the uterus and gonads presenting as cords is one of the diagnostic criteria indicating gonadal dysgenesis. Echographic examinations carried out over the course of therapy yield a more accurate picture of ovarian function. No increase in uterine size on the echogram after discontinuation of hormonal therapy and the appearance of follicles in the ovaries after treatment point to normally functioning ovaries and helps specify the origin of sexual development retardation. In sexual development retardation of a central origin ultrasonic scanning helps assess the therapy efficacy and predict its outcome.